Got mine Sept 8th and have a few minor complaints about mine.
First, Fan noise was an issue without tweaking. The CPU fan is fine, when idle and doing light tasks, that fan will rarely ramp up loud enough to be heard. However, on default Powerplay settings the video card is set on Max Performance on AC which causes the video card fan to ramp up shortly after boot to exhaust the heat even when the laptop has been idle doing nothing. Users who don't fiddle around with ATI's Control Panel or Catalyst Control Centre to adjust Powerplay may find this unacceptable.
Even with Powerplay set on Optimal Battery to underclock the video card, when the laptop is idle on a desk or flat surface, occassionally the fan will ramp up for nearly a minute to cool the card.
I monitored the temperatures using the Everest and Speedfan and found the video card fan is off till the GPU reaches ~58-59 C where the fan comes on and spins at ~2400rpm until the temp falls back down to ~51 C. While not too loud, it just seems out of place when the laptop isn't doing anything graphically intensive and the fan comes on.
With speedfan, I tested what would happen if I forced the fan not to come on. The GPU temp stabilized at 70 C, which ain't overly high, but then Asus probably had a good reason to want to keep the temp below 60 C.
Currently, what I'm doing is manually setting the fan to 35% through Speedfan. At this setting, the video card fan is very quiet, basically inaudible in most daytime environments. This also keeps the GPU temp in the mid 50's when not doing anything graphically intensive.
Second, when using the laptop on my lap/legs while wearing shorts, there's a small hard plastic foot on the bottom far right (near my right knee) that digs into the skin. This was on the second or third day of class with my laptop and I found myself shifting my leg so the plastic would dig into different areas. This however isn't a problem when I'm wearing jeans.
Third, the keyboard for the most part is good (no flexing) but there are a few things with it. Several times I've had my fingertips snag on the bottom of keys while typing. It doesn't happen much, but often enough that I can't dismiss it. Also, the larger the key is the louder they are when pressed. The letters are very quiet but the space bar isn't. When typing quickly during class, the space bar almost sounds like i'm using it to tap the beat of a song fast paced song.