When I lift up my Z70V, I normally pry upwards a bit on the "lip" to get some space between the table and the tilted laptop. Then I get my all my fingers/palm to the actual bottom of the laptop before doing the final lifting.
I tend to be more "careful" when lifting up on the lip because I don't think anybody should be putting too much torque around there. I would imagine in the VERY long run, if you put a lot of force on that overhang, the structure will eventually weaken significantly... but again, that's in the very long run.
Generally speaking, I think this overhang does cause me to be concerned, but the actual chance for damage is close to nil.
When carrying the bare laptop in one hand, flush to the side of my body, I would NOT have the overhanging edge pointed downwards in my palm. The only comfortable and relatively safer way would be to carry with the back edge (where all the ports are) downwards in my palm.
This is just my picky opinion on how the overhang changes your day-to-day handling with the laptop, but please don't think this should change your purchasing decision. I don't think this is a big deal at all, even though I thought it would be when I first bought my Z70V.