Yes. Does help, of course! At least, it gives me another idea.

I'm not running the programs you have, but your mentioning "virtual drives" makes me think about PowerQuest Drive Image, which always keeps a process (pqv2isvc.exe) running on my machine, even when the program itself is not in use.
As soon as I have the time, I'll try getting rid of this process. I think it keeps track of the things that happen on the drives you made backups from. But I don't really see, why this is necessarily done all the time.
Maybe killing this process (pqv2isvc.exe) changes something to the better.