I'm running the E6850, 8800GTX, 2GB Ram, and the ASUS P5N32-E SLI board (but only running one video card atm).
My screenshots were at 1920x1200. I've found with tweaking, I can run it nicely at this res. Main thing I've done is turn shadows and shaders to medium, keeping other items at High - Very High. Still playing around with it, but getting 40-50 FPS and it looks good.