ram - yes, the second piece of ram can only be accessed from the inside, but it shouldn't be too difficult to do the upgrade - some people in my F3k thread mentioned that they'd done it
speakers - though the mid and high tones sound totally fine, there's a noticeable lack of bass; i plug in my desktop sound system w/ subwoofer, and the song sounds completely different
LCD - it's definitely not as clear as my CRT which is why I hook that up to it every chance I get, but when compared to the desktop LCD displays of the G4s at my school, it's not far behind. what really bothers me is the viewing angle, especially the vertical. the viewing angles are definitely not as good as mainstream desktop LCD displays. bottom line? don't expect crazy performance out of the screen, because while it's not worse than average, it's not far better either.
Placement of Home/End - yes, it's damn annoying but you learn to live with it when the keyboard's so nicely shaped. I cannot stress enough how awesome it is to be able to type on a laptop keyboard the same way you do on a full-size desktop keyboard, not having to scrunch your fingers together the way you would with any other laptop =)