The major differences are obvious; notebook components are compact and you need to ensure your components match the interface (i.e. 144pin vs 200pin memory modules).
The next thing to pay certain attention to is heat. DO NOT forget to expose that thermal conductor pad that sits on the cpu core or clean it off and use something more effective in its place. This, I am sure of, you remember from building desktops.
Static discharge is easily mitigated. Yes, you could wear the wrist strap.... I even read a fellow telling a builder to wipe himself and his components down with a dryer sheet. -That one would not be on the top of my list, alrighty.
Just take the precautions to ensure you, the notebook, and the ram are at the same potential. The same precautions you used assembling your desktop still apply.
But more often than not here are the two most common reasons a build goes bad:
1) Wrong Component interface - brute force will not fix this
2) Haste is the mother of Ugly - if you do not plan your assembly, clean a work area, set asside the proper time without distractions, and move at a patient pace, you can be certain that good results will be a matter of luck.
I wish you a clean, happy assembly
Sua Sponte
